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and D.W.S

Glutamate synthesis and degradation in differently located astrocytes was envisaged to present a possible problem in the suggested interacting pathways of glutamate production and oxidation with its exclusive use of aspartate aminotransferase (Figure 3B) rather than GDH (Hertz, 2011a)

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doi: 10.1007/s13402-020-00575-9 238 LembergKMVornovJJRaisRSlusherBS

Rigorous, well-controlled human clinical trials are the necessary next step to validate these promising preclinical findings